Why You’ll Love This Southern Meatloaf

This Southern Nana’s Meatloaf is a true staple of comfort food. With its juicy interior, perfectly balanced seasoning, and a glaze that hits the sweet and tangy notes just right, this recipe brings you back to your grandma’s kitchen table. Whether you’re feeding a hungry family or craving a nostalgic bite, this dish delivers every single time.

Ingredients & Their Purpose

• 2 lbs ground beef (80/20 blend): The perfect ratio of fat to lean for a moist, flavorful loaf.
• 1 cup breadcrumbs: Helps bind the meat together while absorbing juices for a tender texture.
• 1 medium onion, finely chopped: Adds aromatic sweetness and moisture.
• 2 cloves garlic, minced: Infuses the meatloaf with depth and savory warmth.
• 1/4 cup milk: Softens the breadcrumbs and keeps the meatloaf moist.
• 2 large eggs: Essential for binding all ingredients into a cohesive loaf.
• 1 tablespoon Worcestershire sauce: Delivers umami and enhances beefy richness.
• 1 teaspoon salt: Brings all the flavors together.
• 1/2 teaspoon black pepper: Adds subtle heat and balance.
• 1/2 teaspoon dried thyme: Offers a light earthy note typical of Southern cooking.
• 1/2 teaspoon dried oregano: Lends a slightly peppery, herbal profile.
• 1/2 teaspoon smoked paprika: Gives a mild smokiness that takes the flavor up a notch.

Step-by-Step Instructions

1. Preheat oven to 350°F (175°C). Line a baking sheet with parchment or lightly grease a loaf pan for easy release.
2. Combine ingredients: In a large mixing bowl, add ground beef, breadcrumbs, chopped onion, garlic, milk, eggs, Worcestershire sauce, salt, pepper, thyme, oregano, and smoked paprika.
3. Mix gently: Use your hands or a spatula to mix until just combined—overmixing can make the meatloaf dense.
4. Shape the loaf: Transfer the mixture into the prepared pan or shape it by hand on a lined sheet. Flatten the top slightly for even baking.
5. Bake: Place in the center of the oven and bake for 50–60 minutes, or until the internal temperature reaches 160°F (71°C).
6. Optional glaze: In the last 10–15 minutes, brush your favorite glaze over the top (ketchup, brown sugar, and mustard blend works beautifully).
7. Rest before slicing: Let the meatloaf rest for 10 minutes after removing it from the oven to retain juices.

Why This Meatloaf Recipe Is Loved

This dish has stood the test of time for a reason. It’s budget-friendly, easy to make, and always a crowd-pleaser. From Sunday dinners to meal prep, Southern Nana’s Meatloaf is as dependable as it is delicious.

Pro Tips for the Best Meatloaf

• Don’t overmix: Gently folding ingredients helps keep your meatloaf light and tender.
• Use a meat thermometer: Ensures doneness without drying it out.
• Add veggies if desired: Diced bell peppers or carrots can add color and nutrition.
• Let it rest: This seals in moisture and makes for clean slices.

Serving Suggestions

Pair this meatloaf with classic Southern sides like creamy mashed potatoes, buttery green beans, or macaroni and cheese. For dessert, nothing beats a warm slice of apple pecan cake with caramel glaze to round out your meal.

Conclusion

Simple, hearty, and full of love, this Southern Nana’s Meatloaf recipe is the definition of down-home comfort. It’s an easy-to-follow recipe that delivers consistent, mouthwatering results. Make it once, and you’ll be asked for it again and again. If you’re searching for the best meatloaf recipe online, you’ve found it right here — Southern flavor at its finest!