Creamed Chicken and Biscuits: The Ultimate Comfort Food Casserole

There’s something undeniably irresistible about a warm, creamy casserole loaded with tender chicken, rich cheese, and fluffy biscuits baked to golden perfection. Our Creamed Chicken and Biscuits casserole is a comforting, hearty dish that combines the best of creamy textures and savory flavors, making it perfect for weeknight dinners or cozy family gatherings. Easy to prepare and bursting with taste, this recipe delivers a soul-satisfying meal that everyone will love.

Ingredients and Their Roles in This Creamed Chicken and Biscuits Recipe

1 ½ teaspoons butter: Used to sauté the onion, adding depth and richness to the base flavor.
1 small onion, chopped: Adds sweetness and aromatic flavor that balances the creamy sauce.
2 pounds cooked chicken, cut or shredded: The star protein, providing tender, juicy bites throughout the casserole.
1 can cream of chicken soup: Creates a luscious, velvety base for the sauce and ties all ingredients together.
½ cup mayonnaise: Adds richness and moisture, enhancing the creaminess and helping bind the casserole.
1 cup milk: Lightens the sauce for a smooth, pourable consistency.
½ cup roasted red peppers, chopped: Infuses a subtle smoky sweetness and adds color and texture contrast.
1 ½ cups mild cheddar cheese: Melts beautifully, providing gooey, cheesy goodness that crowns the casserole.
1 can refrigerated biscuit dough: Quick and easy biscuit topping that bakes into soft, fluffy pockets atop the creamy chicken base.

Step-by-Step Instructions to Make Creamed Chicken and Biscuits Casserole

Preheat the oven to 350°F (175°C). Prepare your baking dish by greasing the bottom and sides to prevent sticking.
Heat the butter in a skillet over medium heat. Add the chopped onion and sauté until it softens and becomes translucent, releasing its sweet aroma.
In a large mixing bowl, combine the cooked chicken, sautéed onion, cream of chicken soup, mayonnaise, milk, and roasted red peppers. Stir well until all ingredients are fully incorporated and the mixture is creamy and smooth.
Pour the creamy chicken mixture evenly into the prepared baking dish. Spread it out to form an even layer.
Bake uncovered for 15 minutes. This allows the flavors to meld and the casserole to warm through.
Remove the casserole from the oven and sprinkle 1 cup of cheddar cheese evenly over the top.
Open the refrigerated biscuit dough and arrange the biscuits in a single layer over the cheese. They will bake into soft, golden biscuits that perfectly complement the creamy chicken below.
Return the casserole to the oven and bake for an additional 15-20 minutes, or until the biscuits are golden brown and cooked through, and the cheese is melted and bubbly.
Once baked, let the casserole sit for a few minutes before serving. This resting time helps the casserole set, making it easier to serve and allowing flavors to deepen.

Why This Creamed Chicken and Biscuits Recipe Is Loved

This dish is a classic for a reason—it’s comfort food at its finest. The combination of creamy chicken mixed with savory roasted red peppers creates a rich flavor profile, while the cheddar cheese adds a melty, indulgent topping. The fluffy biscuits baked on top bring a delightful texture contrast, making every bite exciting and satisfying. Plus, using refrigerated biscuit dough makes it incredibly quick and simple to prepare, perfect for busy weeknights or when you want a hassle-free meal with minimal cleanup.

Pro Tips for Perfecting Your Creamed Chicken and Biscuits Casserole

Use freshly cooked or rotisserie chicken for juicy, tender meat. Leftovers work perfectly.
Don’t skip sautéing the onion —it adds sweetness and depth you won’t get from raw onion.
Make sure the butter and baking dish are well greased to prevent sticking and help biscuits brown evenly.
For extra flavor, add a pinch of garlic powder or smoked paprika to the creamy mixture.
Use mild cheddar for a smooth melt, or sharp cheddar for a bolder taste.
Serve immediately after resting to enjoy the biscuits soft and warm.

Serving Suggestions to Complete Your Meal

This casserole shines as a complete meal on its own, but pairing it with a fresh green salad with a tangy vinaigrette or steamed seasonal vegetables adds a refreshing balance. A side of roasted potatoes or a light coleslaw also complements the creamy richness beautifully.

For a cozy dinner, consider serving it with warm crusty bread and a glass of your favorite white wine or iced tea. For leftovers, this dish reheats well and makes fantastic lunches.

Conclusion: Simple, Delicious, and Perfectly Comforting

Our Creamed Chicken and Biscuits casserole is a foolproof recipe that combines ease with irresistible flavors and textures. From the creamy chicken base to the cheesy blanket of golden biscuits, every bite delivers comfort and satisfaction. It’s a dish that brings warmth to the table with minimal effort but maximum taste, ideal for family dinners, potlucks, or any time you crave a classic homemade meal.

Give this recipe a try and discover why it’s a beloved staple in comfort food kitchens everywhere. With its straightforward ingredients and simple preparation steps, it’s sure to become a fast favorite that you return to time and time again.